Nanotechnology in pharmaceutical development
Nanoparticles have been developed for a range of applications in healthcare products from therapeutics, medical devices, drug delivery, diagnostics, disease and infection prevention. Innoworks provides a comprehensive R&D nanotechnology systems coupled with it's suite of relevant analytical technology for pharmaceutical product development for niche therapeutic segments.
Innoworks has extensive experience with dispersed polymeric nanoparticulate systems and liposomal nanoemulsions for drug delivery as well as its specialized analysis and characterization techniques per QbD.
Innoworks has extensive experience with dispersed polymeric nanoparticulate systems and liposomal nanoemulsions for drug delivery as well as its specialized analysis and characterization techniques per QbD.
Physical characterization
Analysis of particle size and morphology using electron microscopy (SEM and TEM).
· Analysis of particle size and morphology using electron microscopy (SEM and TEM).
· Particle size determination using light scattering techniques or disc centrifugation.
· Nanoparticle interactions to aid formulation development by zeta potential measurements.
· Physical chemical properties (viscosity, solubility and more).
· Surface area measurements by BET isotherm.
· Crystal morphology by powder X-Ray Diffraction.
· Analysis of particle size and morphology using electron microscopy (SEM and TEM).
· Particle size determination using light scattering techniques or disc centrifugation.
· Nanoparticle interactions to aid formulation development by zeta potential measurements.
· Physical chemical properties (viscosity, solubility and more).
· Surface area measurements by BET isotherm.
· Crystal morphology by powder X-Ray Diffraction.
Particle Sizing of Nano-dispersion with photon cross-correlation spectroscopy (PCCS).
Nanometer particle sizing of nano-disperions, from 1 nm to microns in diameter, is possible using Photon Cross Correlation Spectroscopy (PCCS). Dispersions or emulsions in both water and non-aqueous liquids and dispersions or emulsions in water of non-aqueous liquids can be analysed. Photon Cross Correlation Spectroscopy (PCCS) allows for the simultaneous measurement of particle size and stability of opaque suspension or emulsions of nanoparticles in the size range of about 1 nm to some microns. PCCS is a powerful extension of the well stablished PCS (also called DLS or QELS; it is restricted in use to very dilute systems so that multiple scattering of the laser light is minimised).
Chemical characterization
- Organic Component Analysis e.g. by using LC-MS/MS.
- Inorganic Elemental Analysis by ICP-MS, ICP-OES, or SEM-EDX.
- Chemical information via FTIR or RAMAN spectroscopy / microscopy or NMR.
- Purity and impurities.
- Surface Chemistry / Surface Analysis.
- Nanoparticles and nanoemulsions in dispersed systems by Dynamic Light Scattering